Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25−Foxp3+ T cells

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25−Foxp3+ T cells

Abstract Background The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β produced by tumor cells promotes tolerance via expansion of Tregs. Our g...

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Bibliographic Details
Main Authors: Magdalena J. Polanczyk, Edwin Walker, Daniel Haley, Bella S. Guerrouahen, Emmanuel T. Akporiaye
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Translational Medicine
Subjects:
TGF-β
SM16
Mice
Treg subsets
Anti-tumor response
Online Access:http://link.springer.com/article/10.1186/s12967-019-1967-3

Internet

http://link.springer.com/article/10.1186/s12967-019-1967-3

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