NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant

NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant

Reactive oxygen species (ROS) play an important role in causing neuronal death in a number of neurological disorders. We recently reported that ROS serve as a signal to activate neuronal apoptosis and axonal degeneration by activating ZNRF1 (zinc- and RING-finger 1), a ubiquitin ligase that targets...

Full description

Bibliographic Details
Main Authors: Shuji Wakatsuki, Toshiyuki Araki
Format: Article
Language:English
Published: Taylor & Francis Group 2016-03-01
Series:Communicative & Integrative Biology
Subjects:
6-hydroxydopamine
apoptosis
caspase
neurodegenerative diseases
oxidative stress
Parkinson's disease
phosphorylation
superoxide
ubiquitin-proteasome system
ZNRF1
Online Access:http://dx.doi.org/10.1080/19420889.2016.1143575

Internet

http://dx.doi.org/10.1080/19420889.2016.1143575

Similar Items