TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy

TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy

Summary: Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease. In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term “tauLUM,”...

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Bibliographic Details
Main Authors: Simon A. Levy, Gabrielle Zuniga, Elias M. Gonzalez, David Butler, Sally Temple, Bess Frost
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Cell Reports: Methods
Subjects:
tau
Alzheimer’s disease
neurodegeneration
split-luciferase
Drosophila
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237522001746

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http://www.sciencedirect.com/science/article/pii/S2667237522001746

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