Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism.

Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism.

Methotrexate (MTX) is a folic acid antagonist used in high doses as an anti-cancer treatment and in low doses for the treatment of some autoimmune diseases. MTX use has been linked to oxidative imbalance, which may cause multi-organ toxicities that can be attenuated by antioxidant supplementation. D...

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Bibliographic Details
Main Authors: Fernanda Barbisan, Jéssica de Rosso Motta, Alexis Trott, Verônica Azzolin, Eduardo Bortoluzzi Dornelles, Matheus Marcon, Thaís Doeler Algarve, Marta Maria Medeiros Frescura Duarte, Clarice Pinheiro Mostardeiro, Taís Cristina Unfer, Karen Lilian Schott, Ivana Beatrice Mânica da Cruz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4203676?pdf=render

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http://europepmc.org/articles/PMC4203676?pdf=render

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