Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the <italic toggle="yes">Brucella</italic> Intracellular Cycle

Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the <italic toggle="yes">Brucella</italic> Intracellular Cycle

ABSTRACT Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is known, how they interact to promote pathogenesis is...

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Bibliographic Details
Main Authors: Erin P. Smith, Alexis Cotto-Rosario, Elizabeth Borghesan, Kiara Held, Cheryl N. Miller, Jean Celli
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
Brucella
Rab2
type IV secretion
epistasis
macrophage
pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/mBio.03350-19

Internet

https://journals.asm.org/doi/10.1128/mBio.03350-19

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