Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits

Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits

Abstract Background Apnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces perinatal intermittent hypoxia (IH), which leads to neurodevelopmental disorders. The impact on the brain has been well investigated. Howeve...

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Bibliographic Details
Main Authors: S. Leroux, A. Rodriguez-Duboc, A. Arabo, M. Basille-Dugay, D. Vaudry, D. Burel
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell & Bioscience
Subjects:
Apnea of prematurity
Intermittent hypoxia
Cerebellum
Purkinje cells
Online Access:https://doi.org/10.1186/s13578-022-00869-5

Internet

https://doi.org/10.1186/s13578-022-00869-5

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