Somatic <it>VHL </it>gene alterations in MEN2-associated medullary thyroid carcinoma

Somatic <it>VHL </it>gene alterations in MEN2-associated medullary thyroid carcinoma

<p>Abstract</p> <p>Background</p> <p>Germline mutations in <it>RET </it>are responsible for multiple endocrine neoplasia type 2 (MEN2), an autosomal dominantly inherited cancer syndrome that is characterized by medullary thyroid carcinoma (MTC), pheochromocy...

Full description

Bibliographic Details
Main Authors:	Pacak Karel, Zhuang Zhengping, Libutti Steven K, Tannapfel Andrea, Vortmeyer Alexander O, Brouwers Frederieke M, Koch Christian A, Neumann Hartmut PH, Paschke Ralf
Format:	Article
Language:	English
Published:	BMC 2006-05-01
Series:	BMC Cancer
Online Access:	http://www.biomedcentral.com/1471-2407/6/131

Similar Items

Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene
by: Koperek, O, et al.
Published: (2011)

Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene.
by: Koperek, O, et al.
Published: (2011)

Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.
by: H-C Jennifer Shen, et al.
Published: (2009-01-01)

Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma
by: Larissa V. Bim, et al.
Published: (2019-07-01)

Histological Tracking into the Third Dimension: Evolution of Early Tumorigenesis in VHL Kidney
by: Mayyan Mubarak, et al.
Published: (2021-09-01)

Histological Tracking into the Third Dimension: Evolution of Early Tumorigenesis in VHL Kidney
by: Mayyan Mubarak, et al.
Published: (2021-09-01)

Progression of Epididymal Maldevelopment Into Hamartoma-like Neoplasia in VHL Disease
by: Gautam U. Mehta, et al.
Published: (2008-10-01)

MEDULLARY THYROID CARCINOMA
by: V. S. Medvedev, et al.
Published: (2015-04-01)

Somatic Mutations in Exons 10, 11, and 16 of the RET Protooncogene in Medullary Thyroid Carcinoma Patients
by: Elham Shakiba, et al.
Published: (2020-09-01)

Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt Tumor Progression
by: Chunzhang Yang, et al.
Published: (2013-01-01)

MEDULLARY THYROID CANCER AS PART OF MEN 2B SYNDROME. CASE REPORT
by: L. N. Lyubchenko, et al.
Published: (2015-04-01)

MEN2A syndrome presenting as medullary thyroid cancer metastasizing into the pheochromocytoma
by: Ying-Lan Tuo, et al.
Published: (2022-05-01)

Trichloroethylene exposure and somatic mutations of the <it>VHL </it>gene in patients with Renal Cell Carcinoma
by: Fevotte Joelle, et al.
Published: (2007-11-01)

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study
by: Rui M B Maciel, et al.
Published: (2019-03-01)

A cohort study on 10-year survival of sporadic medullary thyroid carcinoma with somatic RET mutation
by: Li-Lun Chuang, et al.
Published: (2016-11-01)

Medullary thyroid cancer: epidemiology
by: S. Rybakov
Published: (2023-06-01)

An update on medullary carcinoma thyroid
by: Mithun Raam, et al.
Published: (2019-01-01)

Familial Medullary Thyroid Carcinoma without MEN Syndrome: A Case Series Study
by: Jamal Jafari Nodooshan, et al.
Published: (2023-04-01)

Clinical decision making in small non-functioning VHL-related incidentalomas
by: Roland Därr, et al.
Published: (2020-09-01)

Update of pathology in medullary thyroid carcinoma
by: LIU Zhiyan, YU Yaling, KAKUDO Kennichi
Published: (2023-11-01)

Educational Case: Medullary Thyroid Carcinoma
by: Carl T. McGary MD, PhD
Published: (2018-06-01)

THE DIAGNOSIS AND TREATMENT OF MEDULLARY THYROID CANCER
by: V. Zh. Brzhezovsky, et al.
Published: (2015-04-01)

An Introduction to Managing Medullary Thyroid Cancer
by: de Groot Jan, et al.
Published: (2006-07-01)

Papillary variant of medullary carcinoma thyroid
by: Saumya Shukla, et al.
Published: (2014-01-01)

Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
by: Sergio PA Toledo, et al.
Published: (2009-01-01)

Medullary Thyroid Cancer: Management Guidelines
by: F M Abdulkhabirova, et al.
Published: (2013-06-01)

RET mutations and medullary thyroid cancer
by: Chia-Chi Lin
Published: (2011-11-01)

Medullary Thyroid Cancer: Management Guidelines
by: F M Abdulkhabirova, et al.
Published: (2012-03-01)

Ceruloplasmin Status in Medullary Thyroid Carcinoma
by: Fatemeh RAZAVI, et al.
Published: (2020-01-01)

Identification of Somatic Mutations in the von Hippel–Lindau (VHL) Gene in a Patient With Renal Cell Carcinoma
by: Wen-Chung Wang, et al.
Published: (2009-11-01)

Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing
by: Raffaele Ciampi, et al.
Published: (2019-10-01)

Calcitonin receptor expression in medullary thyroid carcinoma
by: Virginia Cappagli, et al.
Published: (2017-09-01)

Mixed Medullary and Follicular Thyroid Carcinoma (MMFTC)
by: Hasnaini Hasnaini, et al.
Published: (2020-11-01)

Diagnosis and treatment of medullary thyroid carcinoma-an update
by: CHEN Chengkun, GUO Bomin, DENG Xianzhao, WU Bo, FAN Youben
Published: (2022-06-01)

Medullary thyroid cancer: a little history
by: S.Y. Rybakov
Published: (2022-11-01)

Thirty synchronous medullary and papillary thyroid carcinomas
by: Daqi Zhang, et al.
Published: (2023-03-01)

Design of new drugs for medullary thyroid carcinoma
by: Yanqing Li, et al.
Published: (2022-12-01)

Integrated proteogenomic characterization of medullary thyroid carcinoma
by: Xiao Shi, et al.
Published: (2022-11-01)

Recent Updates on the Management of Medullary Thyroid Carcinoma
by: Bo Hyun Kim, et al.
Published: (2016-09-01)

Aggressive clinical course of medullary thyroid microcarcinoma
by: Janić Tamara, et al.
Published: (2022-01-01)