Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...

Full description

Bibliographic Details
Main Authors: Traian Sulea, Nazanin Rohani, Jason Baardsnes, Christopher R. Corbeil, Christophe Deprez, Yuneivy Cepero-Donates, Alma Robert, Joseph D. Schrag, Marie Parat, Mélanie Duchesne, Maria L. Jaramillo, Enrico O. Purisima, John C. Zwaagstra
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Virtual histidine scanning
acidic pH selectivity
cell binding
spheroid growth
tumor targeting
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1682866

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2019.1682866

Similar Items