EGFR exon 20 insertion mutations and response to osimertinib in non-small-cell lung cancer

EGFR exon 20 insertion mutations and response to osimertinib in non-small-cell lung cancer

Abstract Background Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4–12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRe...

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Bibliographic Details
Main Authors: Wenfeng Fang, Yihua Huang, Shaodong Hong, Zhonghan Zhang, Minghui Wang, Jiadi Gan, Wenjing Wang, Honglin Guo, Kai Wang, Li Zhang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
NSCLC
EGFRex20ins
NGS
Osimertinib
Online Access:http://link.springer.com/article/10.1186/s12885-019-5820-0

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http://link.springer.com/article/10.1186/s12885-019-5820-0

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