Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran <b>11</b> and 3-oxabicyclo [3.3.1]nonane <b>12</b> scaffolds were discovered. These monoterpene-derived compounds were synthesized through preliminary isomerization of...

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Main Authors: Irina V. Il’ina, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Alexander Yu. Sidorenko, Nikolay S. Li-Zhulanov, Dina V. Korchagina, Raina Chand, Daniel M. Ayine-Tora, Arina A. Chepanova, Olga D. Zakharova, Ekaterina S. Ilina, Jóhannes Reynisson, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
monoterpene
carene
topotecan
tyrosyl-DNA phosphodiesterase 1
synergy
<i>TDP1</i> gene knockout cells
Online Access:https://www.mdpi.com/1420-3049/25/15/3496

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https://www.mdpi.com/1420-3049/25/15/3496

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