Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes

Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes

In 2019, synthetic cannabinoids accounted for more than one-third of new drugs of abuse worldwide; however, assessment of associated health risks is not ethical for controlled and often illegal substances, making CD-1 mouse exposure studies the gold standard. Interpretation of those findings then de...

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Bibliographic Details
Main Authors: Samantha V. Crosby, Izzeldin Y. Ahmed, Laura R. Osborn, Zeyuan Wang, Mary A. Schleiff, William E. Fantegrossi, Swati Nagar, Paul L. Prather, Gunnar Boysen, Grover P. Miller
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Metabolites
Subjects:
synthetic cannabinoid
5F-APINACA
5F-AKB48
P450
metabolism
enzyme kinetics
Online Access:https://www.mdpi.com/2218-1989/12/8/773

Internet

https://www.mdpi.com/2218-1989/12/8/773

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