Novel Surrogate Neutralizing Assay Supports Parvovirus B19 Vaccine Development for Children with Sickle Cell Disease

Novel Surrogate Neutralizing Assay Supports Parvovirus B19 Vaccine Development for Children with Sickle Cell Disease

Children with sickle cell disease (SCD) suffer life-threatening transient aplastic crisis (TAC) when infected with parvovirus B19. In utero, infection of healthy fetuses may result in anemia, hydrops, and death. Unfortunately, although promising vaccine candidates exist, no product has yet been lice...

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Bibliographic Details
Main Authors: Rhiannon R. Penkert, Sumana Chandramouli, Philip R. Dormitzer, Ethan C. Settembre, Robert E. Sealy, Susan Wong, Neal S. Young, Yilun Sun, Li Tang, Alyssa Cotton, Jola Dowdy, Randall T. Hayden, Jane S. Hankins, Julia L. Hurwitz
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
parvovirus B19
VP1u
neutralization assay
aplastic crisis
sickle cell disease
vaccine
Online Access:https://www.mdpi.com/2076-393X/9/8/860

Internet

https://www.mdpi.com/2076-393X/9/8/860

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