Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions

Convenient and efficient N-methylation of secondary amines under solvent-free ball milling conditions

Abstract In the present work, we report the development of a rapid, efficient, and solvent-free procedure for the N-methylation of secondary amines under mechanochemical conditions. After optimization of the milling parameters, a vibrational ball mill was used to synthesize 26 tertiary N-methylated...

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Bibliographic Details
Main Authors: Mikołaj Walter, Olga Ciupak, Karol Biernacki, Janusz Rachoń, Dariusz Witt, Sebastian Demkowicz
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Mechanochemistry
Vibrational ball mill
Amines
N-methylation
Solvent-free synthesis
Online Access:https://doi.org/10.1038/s41598-024-59374-z

Internet

https://doi.org/10.1038/s41598-024-59374-z

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