NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer
A schematic illustration showing that SCLC-derived exosomes polarize M2 macrophages to promote SCLC metastasis through the NLRP6/NF-κB pathway.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-10-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05336-0 |
| _version_ | 1811249961614966784 |
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| author | Xinrui Rao Xiaoshu Zhou Geng Wang Xiaohua Jie Biyuan Xing Yingzhuo Xu Yunshang Chen Jun Li Kuikui Zhu Zilong Wu Gang Wu Chuangyan Wu Rui Zhou |
| author_facet | Xinrui Rao Xiaoshu Zhou Geng Wang Xiaohua Jie Biyuan Xing Yingzhuo Xu Yunshang Chen Jun Li Kuikui Zhu Zilong Wu Gang Wu Chuangyan Wu Rui Zhou |
| author_sort | Xinrui Rao |
| collection | DOAJ |
| description | A schematic illustration showing that SCLC-derived exosomes polarize M2 macrophages to promote SCLC metastasis through the NLRP6/NF-κB pathway. |
| first_indexed | 2024-04-12T15:55:37Z |
| format | Article |
| id | doaj.art-f7f843219caf41b1b634a97c83731819 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-12T15:55:37Z |
| publishDate | 2022-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-f7f843219caf41b1b634a97c837318192022-12-22T03:26:22ZengNature Publishing GroupCell Death and Disease2041-48892022-10-01131011210.1038/s41419-022-05336-0NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancerXinrui Rao0Xiaoshu Zhou1Geng Wang2Xiaohua Jie3Biyuan Xing4Yingzhuo Xu5Yunshang Chen6Jun Li7Kuikui Zhu8Zilong Wu9Gang Wu10Chuangyan Wu11Rui Zhou12Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyA schematic illustration showing that SCLC-derived exosomes polarize M2 macrophages to promote SCLC metastasis through the NLRP6/NF-κB pathway.https://doi.org/10.1038/s41419-022-05336-0 |
| spellingShingle | Xinrui Rao Xiaoshu Zhou Geng Wang Xiaohua Jie Biyuan Xing Yingzhuo Xu Yunshang Chen Jun Li Kuikui Zhu Zilong Wu Gang Wu Chuangyan Wu Rui Zhou NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer Cell Death and Disease |
| title | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer |
| title_full | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer |
| title_fullStr | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer |
| title_full_unstemmed | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer |
| title_short | NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer |
| title_sort | nlrp6 is required for cancer derived exosome modified macrophage m2 polarization and promotes metastasis in small cell lung cancer |
| url | https://doi.org/10.1038/s41419-022-05336-0 |
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