Plant production of high affinity nanobodies that block SARS-CoV-2 spike protein binding with its receptor, human angiotensin converting enzyme

Plant production of high affinity nanobodies that block SARS-CoV-2 spike protein binding with its receptor, human angiotensin converting enzyme

Nanobodies® (VHH antibodies), are small peptides that represent the antigen binding domain, VHH of unique single domain antibodies (heavy chain only antibodies, HcAb) derived from camelids. Here, we demonstrate production of VHH nanobodies against the SARS-CoV-2 spike proteins in the solanaceous pla...

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Bibliographic Details
Main Authors: Marco Pitino, Laura A. Fleites, Lauren Shrum, Michelle Heck, Robert G. Shatters
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
SARS-CoV-2
nanobody
plant
VHH
competitive ELISA
ACE2
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1045337/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.1045337/full

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