Using circulating microbial cell-free DNA to identify persistent Treponema pallidum infection in serofast syphilis patients

Using circulating microbial cell-free DNA to identify persistent Treponema pallidum infection in serofast syphilis patients

Summary: The question of whether serofast status of syphilis patients indicates an ongoing low-grade Treponema pallidum (T. pallidum) infection remains unanswered. To address this, we developed a machine learning model to identify T. pallidum in cell-free DNA (cfDNA) using next-generation sequencing...

Detaylı Bibliyografya
Asıl Yazarlar:	Meng Yin Wu, Lu Chen, Li Cheng Liu, Ming Juan Liu, Yan Feng Li, He Yi Zheng, Ling Leng, Yi Jun Zou, Wei Jun Chen, Jun Li
Materyal Türü:	Makale
Dil:	English
Baskı/Yayın Bilgisi:	Elsevier 2024-04-01
Seri Bilgileri:	iScience
Konular:	Microbiology
Online Erişim:	http://www.sciencedirect.com/science/article/pii/S2589004224006205

Benzer Materyaller

Molecular subtyping of Treponema pallidum and associated factors of serofast status in early syphilis patients: Identified novel genotype and cytokine marker.
Yazar:: Rui-Li Zhang, ve diğerleri
Baskı/Yayın Bilgisi: (2017-01-01)

Predictors of serofast state after treatment of patients with syphilis
Yazar:: Xiao-Ke Liu, ve diğerleri
Baskı/Yayın Bilgisi: (2020-12-01)

Treponema Pallidum epidermotropism in nodular secondary syphilis
Yazar:: Jorge Magdaleno-Tapial, ve diğerleri
Baskı/Yayın Bilgisi: (2018-01-01)

The binary protein interactome of Treponema pallidum--the syphilis spirochete.
Yazar:: Björn Titz, ve diğerleri
Baskı/Yayın Bilgisi: (2008-05-01)

Interaction of Treponema pallidum, the syphilis spirochete, with human platelets.
Yazar:: Brigette Church, ve diğerleri
Baskı/Yayın Bilgisi: (2019-01-01)

A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum
Yazar:: Karen V. Lithgow, ve diğerleri
Baskı/Yayın Bilgisi: (2017-02-01)

Molecular characterization of Treponema pallidum Antigens and their use in Serodiagnosis of Syphilis
Yazar:: , SCHOULS, Leendert Marinus, ve diğerleri
Baskı/Yayın Bilgisi: (1991)

Confirmed Treponema pallidum pleural effusion in patient with known syphilis
Yazar:: Rachel Shadbolt, ve diğerleri
Baskı/Yayın Bilgisi: (2024-12-01)

Performance of Treponema pallidum recombinant proteins in the serological diagnosis of syphilis.
Yazar:: Ângelo Antônio Oliveira Silva, ve diğerleri
Baskı/Yayın Bilgisi: (2020-01-01)

Treponema pallidum Subspecies Pallidum Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis
Yazar:: H. C. A. Zondag, ve diğerleri
Baskı/Yayın Bilgisi: (2022-08-01)

Detection of Treponema pallidum subspecies pallidum for the diagnosis of congenital syphilis by nested polymerase chain reaction
Yazar:: Gladys Pinilla, ve diğerleri
Baskı/Yayın Bilgisi: (2018-03-01)

Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry.
Yazar:: Kara K Osbak, ve diğerleri
Baskı/Yayın Bilgisi: (2016-09-01)

A longitudinal evaluation of <it>Treponema pallidum</it> PCR testing in early syphilis
Yazar:: Shields Matt, ve diğerleri
Baskı/Yayın Bilgisi: (2012-12-01)

Use of Treponema pallidum PCR in Testing of Ulcers for Diagnosis of Primary Syphilis
Yazar:: Angèle Gayet-Ageron, ve diğerleri
Baskı/Yayın Bilgisi: (2015-01-01)

Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
Yazar:: Man Xu, ve diğerleri
Baskı/Yayın Bilgisi: (2021-11-01)

Treponema pallidum protein Tp0136 promotes angiogenesis to facilitate the dissemination of Treponema pallidum
Yazar:: Wei Li, ve diğerleri
Baskı/Yayın Bilgisi: (2024-12-01)

Analysis of Treponema pallidum DNA and CXCL13 in Cerebrospinal Fluid in HIV-Negative Syphilis Patients
Yazar:: Yang L, ve diğerleri
Baskı/Yayın Bilgisi: (2022-12-01)

Quantified Detection of Treponema pallidum DNA by PCR Assays in Urine and Plasma of Syphilis Patients
Yazar:: Cuini Wang, ve diğerleri
Baskı/Yayın Bilgisi: (2022-04-01)

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.
Yazar:: Lorenzo Giacani, ve diğerleri
Baskı/Yayın Bilgisi: (2012-01-01)

ANALYSIS OF Treponema pallidum RECOMBINANT ANTIGENS FOR DIAGNOSIS OF SYPHILIS BY WESTERN BLOTTING TECHNIQUE
Yazar:: Neuza Satomi SATO, ve diğerleri
Baskı/Yayın Bilgisi: (1999-03-01)

Insights into the genetic variation profile of tprK in Treponema pallidum during the development of natural human syphilis infection.
Yazar:: Dan Liu, ve diğerleri
Baskı/Yayın Bilgisi: (2019-07-01)

A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis
Yazar:: Grillova, L, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis
Yazar:: Linda Grillova, ve diğerleri
Baskı/Yayın Bilgisi: (2019-01-01)

Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis.
Yazar:: Emily Romeis, ve diğerleri
Baskı/Yayın Bilgisi: (2023-03-01)

Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. pallidum.
Yazar:: Vitomir Djokic, ve diğerleri
Baskı/Yayın Bilgisi: (2019-05-01)

Whole genome sequence of Treponema pallidum ssp. pallidum, strain Mexico A, suggests recombination between yaws and syphilis strains.
Yazar:: Helena Pětrošová, ve diğerleri
Baskı/Yayın Bilgisi: (2012-01-01)

Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete, Treponema pallidum
Yazar:: Simon Houston, ve diğerleri
Baskı/Yayın Bilgisi: (2022-05-01)

Phylogeny and antibiotic resistance of Treponema pallidum subsp. pallidum
Yazar:: Nosov N.Yu., ve diğerleri
Baskı/Yayın Bilgisi: (2023-06-01)

Molecular investigation of Treponema pallidum strains associated with ocular syphilis in the United States, 2016–2020
Yazar:: Allan Pillay, ve diğerleri
Baskı/Yayın Bilgisi: (2024-10-01)

Syphilis and the host: multi-omic analysis of host cellular responses to Treponema pallidum provides novel insight into syphilis pathogenesis
Yazar:: Sean Waugh, ve diğerleri
Baskı/Yayın Bilgisi: (2023-09-01)

Molecular Characteristics of Macrolide Resistance in Treponema pallidum from Patients with Latent Syphilis in Xinjiang, China
Yazar:: Wang X, ve diğerleri
Baskı/Yayın Bilgisi: (2023-03-01)

Immunization with Tp0954, an adhesin of Treponema pallidum, provides protective efficacy in the rabbit model of experimental syphilis
Yazar:: Yuxing He, ve diğerleri
Baskı/Yayın Bilgisi: (2023-03-01)

Cytokine expression in Treponema pallidum infection
Yazar:: N. Kojima, ve diğerleri
Baskı/Yayın Bilgisi: (2019-06-01)

High increase of Nichols-like clade circulating Treponema pallidum subsp. pallidum in Barcelona from 2021 to 2023
Yazar:: Patricia Nadal-Barón, ve diğerleri
Baskı/Yayın Bilgisi: (2024-10-01)

Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.
Yazar:: Helena Pětrošová, ve diğerleri
Baskı/Yayın Bilgisi: (2013-01-01)

Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol
Yazar:: Ethan Osias, ve diğerleri
Baskı/Yayın Bilgisi: (2020-06-01)

Comparison of a Recombinant-antigen Enzyme Immunoassay with Treponema pallidum Hemagglutination Test for Serological Confirmation of Syphilis
Yazar:: Islay Rodríguez, ve diğerleri
Baskı/Yayın Bilgisi: (2002-04-01)

Detection of Treponema pallidum by seminested PCR in the cerebrospinal fluid of asymptomatic HIV-infected patients with latent syphilis
Yazar:: D. Fraga, ve diğerleri
Baskı/Yayın Bilgisi: (2014-04-01)

Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis
Yazar:: Ei T. Aung, ve diğerleri
Baskı/Yayın Bilgisi: (2023-10-01)

Whole genome sequence of the Treponema pallidum subsp. pallidum strain Amoy: An Asian isolate highly similar to SS14.
Yazar:: Man-Li Tong, ve diğerleri
Baskı/Yayın Bilgisi: (2017-01-01)