Adenosine A2A receptor as a potential regulator of Mycobacterium leprae survival mechanisms: new insights into leprosy neural damage

Adenosine A2A receptor as a potential regulator of Mycobacterium leprae survival mechanisms: new insights into leprosy neural damage

BackgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae, which can lead to a disabling neurodegenerative condition. M. leprae preferentially infects skin macrophages and Schwann cells–glial cells of the peripheral nervous system. The infection modifies the host cell lipid me...

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Main Authors: Plinio Marcos Freire dos Santos, Chyntia Carolina Díaz Acosta, Thabatta Leal Silveira Andrezo Rosa, Michelle Harumi Ishiba, André Alves Dias, Antonio Marcos Rodrigues Pereira, Luísa Domingos Gutierres, Melissa Pontes Pereira, Matheus da Silva Rocha, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, José Roberto Meyer-Fernandes, Fabricio da Mota Ramalho Costa, Maria Angela M. Marques, John T. Belisle, Roberta Olmo Pinheiro, Luciana Silva Rodrigues, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Pharmacology
Subjects:
Leprosy
schwann cell
M. leprae
adenosinergic system
A2A receptor
lipid droplet
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1399363/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1399363/full

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