Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.

Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.

The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial. In these studies, we used Cre-loxP recombination, in which...

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Bibliographic Details
Main Authors: Ryan C Riddle, Cassandra R Diegel, Julie M Leslie, Kyle K Van Koevering, Marie-Claude Faugere, Thomas L Clemens, Bart O Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3651091?pdf=render

Internet

http://europepmc.org/articles/PMC3651091?pdf=render

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