Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation

Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation

BackgroundThe utilization of donation after circulatory death (DCD) hearts can enlarge the donor pool. However, DCD hearts suffer from serious ischemia/reperfusion injury (IRI). Recent studies found that the activation of NLRP3 inflammasome could play a significant role in organ IRI. Mcc950, which i...

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Bibliographic Details
Main Authors: Liwei Xu, Zifeng Zeng, Chuanjie Niu, Deshen Liu, Shaoyan Lin, Xiu Liu, Gábor Szabó, Jun Lu, Shaoyi Zheng, Pengyu Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart transplantation
cardiovascular diseases
NLRP3
MCC950
donation after circulatory death
myocardial ischemia/reperfusion injury
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1126391/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1126391/full

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