Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer

Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer

Abstract Gastric cancer ranks the fifth most common and third leading cause of cancer‐related deaths worldwide. Alterations in the RTK/MAPK, WNT, cell adhesion, TP53, TGFβ, NOTCH, and NFκB signaling pathways could be identified as main oncogenic drivers. A combination of altered pathways can be asso...

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Bibliographic Details
Main Authors: Therese Seidlitz, Tim Schmäche, Fernando Garcίa, Joon Ho Lee, Nan Qin, Susan Kochall, Juliane Fohgrub, David Pauck, Alexander Rothe, Bon‐Kyoung Koo, Jürgen Weitz, Marc Remke, Javier Muñoz, Daniel E Stange
Format: Article
Language:English
Published: Springer Nature 2022-10-01
Series:EMBO Molecular Medicine
Subjects:
gastric cancer
HDACi
MAPK
organoids
Online Access:https://doi.org/10.15252/emmm.202215705

Internet

https://doi.org/10.15252/emmm.202215705

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