Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets

Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets

The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D). HA plays a critical role in T1D pathogenesis, as spontaneous disease is blocked in mice fed the HA synthesis inhibitor 4-methylumbelliferone (4MU). T...

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Bibliographic Details
Main Authors: John A. Gebe, Michel D. Gooden, Gail Workman, Nadine Nagy, Paul L. Bollyky, Thomas N. Wight, Robert B. Vernon
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Matrix Biology Plus
Subjects:
4-methylumbelliferone
Hyaluronan synthases
Implant
Mouse
T cell
Type 1 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028520300338

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http://www.sciencedirect.com/science/article/pii/S2590028520300338

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