Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology

Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology

In recent years, long noncoding RNAs (lncRNAs) have emerged as multifaceted regulators of gene expression, controlling key developmental and disease pathogenesis processes. However, due to the paucity of lncRNA loss-of-function mouse models, key questions regarding the involvement of lncRNAs in orga...

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Bibliographic Details
Main Authors: Nils R. Hansmeier, Pia J. M. Widdershooven, Sajjad Khani, Jan-Wilhelm Kornfeld
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Non-Coding RNA
Subjects:
long noncoding RNA, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome engineering, knockout mice
Online Access:https://www.mdpi.com/2311-553X/5/1/12

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https://www.mdpi.com/2311-553X/5/1/12

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