Effects of psilocybin, psychedelic mushroom extract and 5-hydroxytryptophan on brain immediate early gene expression: Interaction with serotonergic receptor modulators

Effects of psilocybin, psychedelic mushroom extract and 5-hydroxytryptophan on brain immediate early gene expression: Interaction with serotonergic receptor modulators

Background: Immediate early genes (IEGs) are rapidly activated and initiate diverse cellular processes including neuroplasticity. We report the effect of psilocybin (PSIL), PSIL-containing psychedelic mushroom extract (PME) and 5-hydroxytryptophan (5-HTP) on expression of the IEGs, cfos, egr1, and e...

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Bibliographic Details
Main Authors: Elad Lerer, Alexander Botvinnik, Orr Shahar, Meitar Grad, Karin Blakolmer, Noam Shomron, Amit Lotan, Bernard Lerer, Tzuri Lifschytz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
psychedelics
psilocybin
5-HTP
hTR
cfos
Egr1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1391412/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1391412/full

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