An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel

An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel

Leucine-rich Glioma-Inactivated protein 1 (LGI1) is expressed in the central nervous system and its genetic loss of function is associated with epileptic disorders. Additionally, patients with LGI1-directed autoantibodies have frequent focal seizures as a key feature of their disease. LGI1 is compos...

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Bibliographic Details
Main Authors: Johanna Extrémet, Oussama El Far, Norbert Ankri, Sarosh R. Irani, Dominique Debanne, Michaël Russier
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
LGI1
Kv1.1
epilepsy
limbic encephalitis
autoantibodies
Online Access:https://www.mdpi.com/2073-4409/11/17/2713

Internet

https://www.mdpi.com/2073-4409/11/17/2713

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