The Interplay Between Biliary Occlusion and Liver Regeneration: Repeated Regeneration Stimuli Restore Biliary Drainage by Promoting Hepatobiliary Remodeling in a Rat Model

The Interplay Between Biliary Occlusion and Liver Regeneration: Repeated Regeneration Stimuli Restore Biliary Drainage by Promoting Hepatobiliary Remodeling in a Rat Model

Background and AimsPatients with malignant biliary obstruction do not seem to benefit from “two-stage hepatectomy” due to an impairment of liver regeneration. We designed a novel model of “repeated regeneration stimuli” in rats mimicking a “two-stage hepatectomy” with selective or complete biliary o...

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Bibliographic Details
Main Authors: Beate Richter, Constanze Sänger, Franziska Mussbach, Hubert Scheuerlein, Utz Settmacher, Uta Dahmen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Surgery
Subjects:
hepatobiliary remodeling
occlusive cholestasis
regeneration stimuli
biliary decompression
experimental surgery
portal vein ligation
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2022.799669/full

Internet

https://www.frontiersin.org/articles/10.3389/fsurg.2022.799669/full

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