Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

IntroductionPhthalates are a class of endocrine-disrupting chemicals that have been shown to negatively correlate with thyroid hormone serum levels in humans and to cause a state of hyperactivity in the thyroid. However, their mechanism of action is not well described at the molecular level.MethodsW...

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Bibliographic Details
Main Authors: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Endocrinology
Subjects:
ATAC-seq
Nthy-ori 3-1
organoids
phthalates
RNA-seq
thyroid
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1200211/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1200211/full

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