Determination of 20(S)-protopanaxadiol in human plasma by HPLC–MS/MS: application to a pharmacokinetic study

Determination of 20(S)-protopanaxadiol in human plasma by HPLC–MS/MS: application to a pharmacokinetic study

A rapid, specific and sensitive HPLC–MS/MS method was developed and validated for the determination of 20(S)-protopanaxadiol (PPD) in human plasma. PPD and the internal standard PD were extracted from plasma by liquid–liquid extraction with cyclohexane–methylene dichloride (2:1, v/v). The separation...

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Bibliographic Details
Main Authors: Feifan Xie, Sanwang Li, Zeneng Cheng, Xingling Liu, Hong Zhang, Peijiong Li, Zhi Liu, Xin Guo, Peng Yu
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
20(S)-Protopanaxadiol
HPLC–MS/MS
Human plasma
Pharmacokinetics
Liquid–liquid extraction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383513000932

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http://www.sciencedirect.com/science/article/pii/S2211383513000932

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