Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus

Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus

Glycogen synthase kinase-3 (GSK3) mediates phosphorylation of several hundred proteins, and its aberrant activity is associated with an array of prevalent disorders. The two paralogs, GSK3α and GSK3β, are expressed ubiquitously and fulfill common as well as unique tasks throughout the body. In the C...

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Bibliographic Details
Main Authors: Aeen Ebrahim Amini, Tsukiko Miyata, Gang Lei, Fuzi Jin, Elizabeth Rubie, Clarrisa A. Bradley, James R. Woodgett, Graham L. Collingridge, John Georgiou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
CA3-CA1 synapses
LTP (long term potentiation)
synaptic plasticity
GSK-3 (glycogen synthase kinase 3)
conditional knock out mice
synaptic function
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.852171/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.852171/full

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