The telomere maintenance mechanism spectrum and its dynamics in gliomas

The telomere maintenance mechanism spectrum and its dynamics in gliomas

Abstract Background The activation of the telomere maintenance mechanism (TMM) is one of the critical drivers of cancer cell immortality. In gliomas, TERT expression and TERT promoter mutation are considered to reliably indicate telomerase activation, while ATRX mutation and/or loss indicates an alt...

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Détails bibliographiques
Auteurs principaux: Sojin Kim, Tamrin Chowdhury, Hyeon Jong Yu, Jee Ye Kahng, Chae Eun Lee, Seung Ah. Choi, Kyung-Min Kim, Ho Kang, Joo Ho Lee, Soon-Tae Lee, Jae-Kyung Won, Kyung Hyun Kim, Min-Sung Kim, Ji Yeoun Lee, Jin Wook Kim, Yong-Hwy Kim, Tae Min Kim, Seung Hong Choi, Ji Hoon Phi, Young-Kyoung Shin, Ja-Lok Ku, Sungyoung Lee, Hongseok Yun, Hwajin Lee, Dokyoung Kim, Kyoungmi Kim, Junho K. Hur, Sung-Hye Park, Seung-Ki Kim, Chul-Kee Park
Format: Article
Langue:English
Publié: BMC 2022-08-01
Collection:Genome Medicine
Sujets:
Glioma
Telomere maintenance mechanism
TERT
ALT
Accès en ligne:https://doi.org/10.1186/s13073-022-01095-x

Internet

https://doi.org/10.1186/s13073-022-01095-x

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