The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer

The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary mo...

Full description

Bibliographic Details
Main Authors:	Ying Pang, Xu Chen, Tongjie Ji, Meng Cheng, Rui Wang, Chunyu Zhang, Min Liu, Jing Zhang, Chunlong Zhong
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	Cancers
Subjects:	alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) death-domain-associated protein (DAXX) DNA damage replication stress tumorigenesis
Online Access:	https://www.mdpi.com/2072-6694/15/8/2228

Similar Items

ATRX/DAXX: Guarding the Genome against the Hazards of ALT
by: Sarah F. Clatterbuck Soper, et al.
Published: (2023-03-01)

Impact of DAXX and ATRX expression on telomere length and prognosis of breast cancer patients
by: Marwa T. Hussien, et al.
Published: (2020-08-01)

Prognostic Significance of Altered ATRX/DAXX Gene in Pancreatic Neuroendocrine Tumors: A Meta-Analysis
by: Fei Wang, et al.
Published: (2021-06-01)

Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas
by: Chang Sun, et al.
Published: (2022-08-01)

ALT Positivity in Human Cancers: Prevalence and Clinical Insights
by: Danny MacKenzie, et al.
Published: (2021-05-01)

The Clinical Implications of Death Domain-Associated Protein (DAXX) Expression
by: Taek Yong Ko, et al.
Published: (2018-06-01)

X‐linked mental retardation‐hypotonic facies syndrome: Exome sequencing identifies novel clinical characteristics associated with c.5182G>C mutation in the ATRX gene
by: Fatemeh Shakarami, et al.
Published: (2022-10-01)

The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas
by: Yujin Lee, et al.
Published: (2017-08-01)

The Multiple Facets of ATRX Protein
by: Martina Valenzuela, et al.
Published: (2021-05-01)

Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function
by: Sara Timpano, et al.
Published: (2020-08-01)

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma
by: Sally L George, et al.
Published: (2020-09-01)

The Role of ATRX in Glioma Biology
by: Pravanya Nandakumar, et al.
Published: (2017-09-01)

Multiple Roles of dXNP and dADD1—<i>Drosophila</i> Orthologs of ATRX Chromatin Remodeler
by: Larisa Melnikova, et al.
Published: (2023-11-01)

A Novel Mutation in ATRX Causes Alpha-Thalassemia X-Linked Intellectual Disability Syndrome in a Han Chinese Family
by: Shaomin Wu, et al.
Published: (2022-01-01)

DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
by: Irina Bogolyubova, et al.
Published: (2021-01-01)

Multimodal-based machine learning strategy for accurate and non-invasive prediction of intramedullary glioma grade and mutation status of molecular markers: a retrospective study
by: Chao Ma, et al.
Published: (2023-05-01)

Insights into Epigenetic Changes Related to Genetic Variants and Cells-of-Origin of Pancreatic Neuroendocrine Tumors: An Algorithm for Practical Workup
by: Oana A. Ciobanu, et al.
Published: (2022-09-01)

Choroidal melanoma with synchronous Fuchs’ adenoma and novel ATRX mutation
by: Elli Harford, et al.
Published: (2022-04-01)

Nuclear Distribution of the Chromatin-Remodeling Protein ATRX in Mouse Early Embryos during Normal Development and Developmental Arrest In Vitro
by: Irina O. Bogolyubova, et al.
Published: (2023-12-01)

ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress
by: Joseph M Cabral, et al.
Published: (2018-11-01)

DNA repair synthesis and histone deposition partner during homologous recombination
by: Amira Elbakry, et al.
Published: (2018-09-01)

ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas
by: Lucie Darmusey, et al.
Published: (2021-04-01)

Inhibition of p53 and ATRX increases telomeric recombination in primary fibroblasts
by: Ion Udroiu, et al.
Published: (2023-09-01)

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
by: Jennifer Garbarino, et al.
Published: (2021-09-01)

TAS102 selectively inhibits proliferation of α-thalassemia mental retardation X-linked gene-deficient glioma cells
by: WANG Long, et al.
Published: (2019-12-01)

The importance of IDH1, ATRX and WT-1 mutations in glioblastoma
by: Gülsün Gülten, et al.
Published: (2020-07-01)

Alpha Thalassemia/Mental Retardation Syndrome X-Linked, the Alternative Lengthening of Telomere Phenotype, and Gliomagenesis: Current Understandings and Future Potential
by: Jenny He, et al.
Published: (2018-01-01)

New heritable ATRX mutation identified by whole exome sequencing and review
by: Zahra Shahbazi, et al.
Published: (2022-02-01)

A mouse model of ATRX deficiency with cognitive deficits and autistic traits
by: Katherine M. Quesnel, et al.
Published: (2023-11-01)

ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain
by: Kieran Ritchie, et al.
Published: (2014-11-01)

Mosaic expression of Atrx in the mouse central nervous system causes memory deficits
by: Renee J. Tamming, et al.
Published: (2017-02-01)

Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis
by: Yingbin Xie, et al.
Published: (2019-12-01)

Comparison of MRI Sequences to Predict ATRX Status Using Radiomics-Based Machine Learning
by: Nabila Gala Nacul Mora, et al.
Published: (2023-06-01)

IDH-1, ATRX AND 1P19Q CO-DELETION IN DIFFUSE GLIOMAS
by: Rabia Javed, et al.
Published: (2020-04-01)

Therapeutic Vulnerability to ATR Inhibition in Concurrent <i>NF1</i> and <i>ATRX</i>-Deficient/ALT-Positive High-Grade Solid Tumors
by: Ming Yuan, et al.
Published: (2022-06-01)

ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
by: David Pladevall-Morera, et al.
Published: (2022-03-01)

Low Protein Expression of both <i>ATRX</i> and <i>ZNRF3</i> as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma
by: Vania Balderrama Brondani, et al.
Published: (2021-01-01)

Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.
by: Marta Kovatcheva, et al.
Published: (2018-01-01)

Effects of Daxx on γ-ray induced apoptosis of HeLa cells
by: TANG Shuangyang, et al.
Published: (2021-10-01)

The association of sex-biased ATRX mutation in female gastric cancer patients with enhanced immunotherapy-related anticancer immunity
by: You Ge, et al.
Published: (2021-03-01)