Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease

Abstract Background Alzheimer’s disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis and modulation of inflammation, and recent evidence suggests a complex relationship between Axl, Mer, and micro...

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Bibliographic Details
Main Authors: Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O’Banion
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Microglia
Neuroinflammation
TAM receptors
Online Access:https://doi.org/10.1186/s12974-022-02397-y

Internet

https://doi.org/10.1186/s12974-022-02397-y

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