MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription

MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription

Abstract Background Dysregulated long non-coding RNAs participate in the development of diabetic cerebral ischemia. This study aimed to investigate the underlying mechanism of lncRNA MALAT1 in diabetic cerebral ischemia. Method Middle cerebral artery occlusion (MCAO) was performed to establish diabe...

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Bibliographic Details
Main Authors: Nan Zhao, Wei Hua, Qi Liu, Yueying Wang, Zhiyi Liu, Sinan Jin, Benshuai Wang, Yuxin Pang, Jiping Qi, Yuejia Song
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Molecular Medicine
Subjects:
Diabetic cerebral ischemia
MALAT1
Pyroptosis
STAT1
Cerebral ischemic reperfusion
Online Access:https://doi.org/10.1186/s10020-023-00637-2

Internet

https://doi.org/10.1186/s10020-023-00637-2

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