Next-Generation Sequencing Data-Based Association Testing of a Group of Genetic Markers for Complex Responses Using a Generalized Linear Model Framework

Next-Generation Sequencing Data-Based Association Testing of a Group of Genetic Markers for Complex Responses Using a Generalized Linear Model Framework

To study the relationship between genetic variants and phenotypes, association testing is adopted; however, most association studies are conducted by genotype-based testing. Testing methods based on next-generation sequencing (NGS) data without genotype calling demonstrate an advantage over testing...

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Bibliographic Details
Main Authors: Zheng Xu, Song Yan, Cong Wu, Qing Duan, Sixia Chen, Yun Li
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Mathematics
Subjects:
next-generation sequencing
association testing
generalized linear model
joint significance test
variable collapse test
genotype calling
Online Access:https://www.mdpi.com/2227-7390/11/11/2560

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https://www.mdpi.com/2227-7390/11/11/2560

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