Computational and experimental pharmacology to decode the efficacy of Theobroma cacao L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice

Computational and experimental pharmacology to decode the efficacy of Theobroma cacao L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice

Background and objective: Doxorubicin is extensively utilized chemotherapeutic drug, and it causes damage to the heart, liver, and kidneys through oxidative stress. Theobroma cacao L (cocoa) is reported to possess protective effects against several chemical-induced organ damages and also acts as an...

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Bibliographic Details
Main Authors: Priyanka P. Patil, Pranjal Kumar, Pukar Khanal, Vishal S. Patil, Harish R. Darasaguppe, Vishwambhar Vishnu Bhandare, Arati Bhatkande, Sudhanshu Shukla, Rajesh K. Joshi, Basanagouda M. Patil, Subarna Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
cocoa
cytotoxicity
doxorubicin
organ toxicity
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1174867/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1174867/full

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