Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment

Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment

Acanthamoeba spp. are free-living parasites that can cause severe infections such as granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK). Polyhexamethylene biguanide (PHMB) is a topical application for AK treatment. However, PHMB is not entirely effective against all Acanthamoeba str...

Full description

Bibliographic Details
Main Authors:	Huang Jian-Ming, Ko Pin-Ju, Huang Chao-Li, Wen Po-Wei, Chen Chun-Hsien, Shih Min-Hsiu, Lin Wei-Chen, Huang Fu-Chin
Format:	Article
Language:	English
Published:	EDP Sciences 2021-01-01
Series:	Parasite
Subjects:	acanthamoeba polyhexamethylene biguanide p450 monooxygenase amoebic keratitis
Online Access:	https://www.parasite-journal.org/articles/parasite/full_html/2021/01/parasite210084/parasite210084.html

Similar Items

Characterizing clinical isolates of Acanthamoeba castellanii with high resistance to polyhexamethylene biguanide in Taiwan
by: Fu-Chin Huang, et al.
Published: (2017-10-01)

The effect of the disulfideisomerase domain containing protein in the defense against polyhexamethylene biguanide of highly tolerant Acanthamoeba at the trophozoite stage
by: Fu-Chin Huang, et al.
Published: (2016-12-01)

Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis
by: Giulio Ferrari, et al.
Published: (2011-11-01)

Diagnosis and Treatment of Acanthamoeba Keratitis
by: Lincoln Lavado Landeo
Published: (2015-10-01)

Combating the causative agent of amoebic keratitis, Acanthamoeba castellanii, using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches
by: Sara S. Abdel-Hakeem, et al.
Published: (2024-06-01)

Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers
by: Yassine Bouattour, et al.
Published: (2018-04-01)

Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii
by: Kuang-Yi Shih, et al.
Published: (2024-08-01)

Determination of Polyhexamethylene Biguanide Hydrochloride Using a Lactone-Rhodamine B-Based Fluorescence Optode
by: Akane Funaki, et al.
Published: (2020-01-01)

Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis
by: Nor F. Kamaruzzaman, et al.
Published: (2017-08-01)

Surveillance of Amoebic Keratitis-Causing Acanthamoebae for Potential Bacterial Endosymbionts in Ontario, Canada
by: Nessika Karsenti, et al.
Published: (2022-06-01)

Carbon Dioxide Gas Sensor Based on Polyhexamethylene Biguanide Polymer Deposited on Silicon Nano-Cylinders Metasurface
by: Nikolay Lvovich Kazanskiy, et al.
Published: (2021-01-01)

Microsporidial stromal keratitis in an immunocompromised patient: Successful management with medical therapy
by: Amanjot Kaur, et al.
Published: (2020-01-01)

Comparative evaluation of chlorhexidine gluconate with alcohol and polyhexamethylene biguanide with Tris-EDTA as antiseptic solutions for pre-operative skin preparation in dogs
by: Nithida Boonwittaya, et al.
Published: (2024-10-01)

Comparison of the effects of povidone-iodine 5%, polyhexamethylene biguanide, and chlorhexidine as a preoperative antiseptic in endophthalmitis prophylaxis in patients undergoing phacoemulsification cataract surgery
by: Alireza Peyman, et al.
Published: (2020-01-01)

The in vitro effect riboflavin combined with or without UVA in Acanthamoeba castellanii
by: Joohee Park, et al.
Published: (2024-11-01)

Polyvinyl Alcohol/Chitosan/Polyhexamethylene Biguanide Phase Separation System: A Potential Topical Antibacterial Formulation with Enhanced Antimicrobial Effect
by: Yunzhou Ni, et al.
Published: (2020-03-01)

In Vitro Stability of the Biological Activity of Voriconazole against <i>Acanthamoeba castellanii</i>
by: Barbara Czerniak Rodrigues, et al.
Published: (2023-06-01)

An Insight into the Genome of Pathogenic and Non-Pathogenic <i>Acanthamoeba</i>
by: Chayan Sharma, et al.
Published: (2022-12-01)

Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants
by: Karan Malhotra, et al.
Published: (2022-09-01)

Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings
by: Luís M. Vaz, et al.
Published: (2023-11-01)

What is the best therapeutic scheme for Acanthamoeba keratitis?
by: Denise de Freitas, et al.
Published: (2014-09-01)

The Autofluorescence Patterns of <i>Acanthamoeba castellanii, Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Effects of Antibiotics and Tetracaine
by: Hari Kumar Peguda, et al.
Published: (2021-07-01)

In Vitro Effect of Pitavastatin and Its Synergistic Activity with Isavuconazole against <i>Acanthamoeba castellanii</i>
by: Hye Jee Hahn, et al.
Published: (2020-08-01)

Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection
by: Francesco Petrillo, et al.
Published: (2024-04-01)

Comprehensive Analysis of Cytochrome P450 Monooxygenases Reveals Insight Into Their Role in Partial Resistance Against Phytophthora sojae in Soybean
by: Praveen Khatri, et al.
Published: (2022-04-01)

Regioselective and enantioselective propargylic hydroxylations catalyzed by P450tol monooxygenases
by: Xu Deng, et al.
Published: (2024-07-01)

Comparative in vitro effectiveness of a novel contact lens multipurpose solution on Acanthamoeba castellanii
by: Alyssa C. Fears, et al.
Published: (2018-10-01)

Polyhexamethylene biguanide promotes adaptive cross-resistance to gentamicin in Escherichia coli biofilms
by: Raphaël Charron, et al.
Published: (2023-12-01)

Case series: Delayed diagnoses of Acanthamoeba keratitis
by: Moon Jeong Lee, et al.
Published: (2020-09-01)

Acanthamoeba epitheliopathy: Importance of early diagnosis
by: Gavin Li, et al.
Published: (2022-06-01)

Cyt02 encodes cytochrome P450 monooxygenase, increasing rice (Oryza sativa L.) resistance to sheath blight
by: Tengda Zheng, et al.
Published: (2025-02-01)

Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies
by: Christian Schulz, et al.
Published: (2023-08-01)

Comparative in vitro Antibacterial Activity of Polyhexamethylene Guanidine Hydrochloride and Polyhexamethylene Guanidine Succinate
by: Kam An Cha, et al.
Published: (2020-05-01)

Enhancing Acanthamoeba diagnostics: rapid detection of viable Acanthamoeba trophozoites and cysts using viability PCR assay
by: J. M. J. Veugen, et al.
Published: (2025-03-01)

Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus
by: Li Qianqian, et al.
Published: (2021-03-01)

The global epidemiology and clinical diagnosis of Acanthamoeba keratitis
by: Yuheng Zhang, et al.
Published: (2023-06-01)

Quantitative proteomic analysis and functional characterization of Acanthamoeba castellanii exosome-like vesicles
by: Wei-Chen Lin, et al.
Published: (2019-10-01)

Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review
by: António Jorge Guiomar, et al.
Published: (2022-12-01)

Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection
by: Binod Rayamajhee, et al.
Published: (2022-09-01)

Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs
by: Domenico Iacopetta, et al.
Published: (2023-05-01)