Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 <i>Pseudomonas aeruginosa</i> Genomes

Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 <i>Pseudomonas aeruginosa</i> Genomes

Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen <i>Pseudomonas aeruginosa</i>. Changes in their DNA binding regions, i.e., palindromic operators, can compromise pump depression and subsequently enhance resistance against several anti...

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Bibliographic Details
Main Authors: María Pérez-Vázquez, Carla López-Causapé, Andrés Corral-Lugo, Michael J. McConnell, Jesús Oteo-Iglesias, Antonio Oliver, Antonio J. Martín-Galiano
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Microorganisms
Subjects:
high-risk clone
multidrug resistance
operator
repressor
resistome
Online Access:https://www.mdpi.com/2076-2607/11/10/2486

Internet

https://www.mdpi.com/2076-2607/11/10/2486

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