The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Pupariation in Drosophila is triggered by the steroid-hormone ecdysone and requires coordination between associated behavioral and body-reshaping motor subprograms. The authors show that coordination requires ecdysone-dependent Dilp8-Lgr3 signaling between the cuticle epidermis and interneurons.

Bibliographic Details
Main Authors: Fabiana Heredia, Yanel Volonté, Joana Pereirinha, Magdalena Fernandez-Acosta, Andreia P. Casimiro, Cláudia G. Belém, Filipe Viegas, Kohtaro Tanaka, Juliane Menezes, Maite Arana, Gisele A. Cardoso, André Macedo, Malwina Kotowicz, Facundo H. Prado Spalm, Marcos J. Dibo, Raquel D. Monfardini, Tatiana T. Torres, César S. Mendes, Andres Garelli, Alisson M. Gontijo
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23218-5

Internet

https://doi.org/10.1038/s41467-021-23218-5

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