TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

The role of TREM2 in Alzheimer’s disease (AD) is not fully understood. Previous studies investigating the effect of TREM2 deletion on tauopathy mouse models without the contribution of b-amyloid have focused only on tau overexpression models. Herein, we investigated the effects of TREM2 deficiency o...

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Bibliographic Details
Main Authors: Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
Alzheimer’s disease
Trem2
microglia
tau propagation
tauopathy
neuroinflammation
Online Access:https://www.mdpi.com/2073-4409/12/12/1597

Internet

https://www.mdpi.com/2073-4409/12/12/1597

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