PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels

PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels

Abstract Background The increased degradation of the insulin receptor β subunit (InsRβ) in lysosomes contributes to the development of insulin resistance and type 2 diabetes mellitus. Endoplasmic reticulum (ER) stress contributes to insulin resistance through several mechanisms, including the reduct...

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Bibliographic Details
Main Authors: Jue-Rui Wang, Javier Jurado-Aguilar, Emma Barroso, Ricardo Rodríguez-Calvo, Antoni Camins, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
PPARβ/δ
InsRβ
EphB4
ER stress
GW5101516
Online Access:https://doi.org/10.1186/s12964-024-01972-5

Internet

https://doi.org/10.1186/s12964-024-01972-5

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