In Vitro Inhibitory Effects of Synthetic Cannabinoid EAM-2201 on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

In Vitro Inhibitory Effects of Synthetic Cannabinoid EAM-2201 on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

EAM-2201, a synthetic cannabinoid, is a potent agonist of the cannabinoid receptors that is widely abused as an illicit recreational drug in combination with other drugs. To evaluate the potential of EAM-2201 as a perpetrator of drug–drug interactions, the inhibitory effects of EAM-2201 on...

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Bibliographic Details
Main Authors: Tae Yeon Kong, Soon-Sang Kwon, Jae Chul Cheong, Hee Seung Kim, Jin Young Kim, Hye Suk Lee
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
EAM-2201
drug–drug interaction
human liver microsomes
cytochrome P450
UDP-glucuronosyltransferase
Online Access:http://www.mdpi.com/1420-3049/23/4/920

Internet

http://www.mdpi.com/1420-3049/23/4/920

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