Structure-based virtual screening for the inhibition and clearance of amyloidosis by small molecules as pharmacological chaperones
The accumulation, processing and toxicity of Aβ can be affected by interacting with transthyretin (TTR). We obtained 31 compounds with different structures by virtual screening based on protein structure. Among them, compound 11 inhibited acid-induced TTR protein amyloid fibrils by 75.57 ± 11.27%,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417423000079 |