Synthesis and antimicrobial screening of novel 1,3-dioxolanes linked to N-5 of 5H-[1,2,4]triazino[5,6-b]indole-3-thiol

Synthesis and antimicrobial screening of novel 1,3-dioxolanes linked to N-5 of 5H-[1,2,4]triazino[5,6-b]indole-3-thiol

Synthesis of 1-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1H-indole- -2,3-dione (10) was achieved by coupling 1H-indole-2,3-dione (16) with (R)- -(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate (15) in the presence of sodium hydride in dry N,N-dimethylformamide at room temperature in a...

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Bibliographic Details
Main Authors: Ramadan El Sayed, Rasheed Hanaa A., El Ashry El Sayed H.
Format: Article
Language:English
Published: Serbian Chemical Society 2019-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
survey
alkylation
dioxolanes
1H-indole-2
3-dione
candida albicans
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800067R.pdf

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http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800067R.pdf

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