Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs

Abstract Concomitant with developing pulmonary hypertension (PH), newborn piglets exposed to chronic hypoxia develop pulmonary vascular NO signaling impairments. PH is reduced and NO signaling is improved in chronically hypoxic piglets treated with the NO‐arginine precursor, L‐citrulline. Folic acid...

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Bibliographic Details
Main Authors: Matthew Douglass, Anna Dikalova, Mark R. Kaplowitz, Yongmei Zhang, Gary Cunningham, Marshall Summar, Candice D. Fike
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.15096