Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells

Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells

Abstract Background Attenuated Oxaliplatin efficacy is a challenge in treating colorectal cancer (CRC) patients, contributory to the failure in chemotherapy and the risks in relapse and metastasis. However, the mechanism of Oxaliplatin de-efficacy during CRC treatment has not been completely elucida...

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Bibliographic Details
Main Authors: Xiaohui Liu, Bo Wu, Hong Chen, Haimei Sun, Xiaoxia Guo, Tingyi Sun, Deshan Zhou, Shu Yang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
ABCC10
Colorectal cancer
Endoplasmic reticulum stress
IRE1α
Oxaliplatin
Unfolded protein response
Online Access:https://doi.org/10.1186/s12885-022-10415-8

Internet

https://doi.org/10.1186/s12885-022-10415-8

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