The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele

The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele

Varicocele is an age-related disease with no current medical treatments positively impacting infertility. Toll-like receptor 4 (TLR4) expression is present in normal testis with an involvement in the immunological reactions. The role of peroxisome proliferator-activated receptor-α (PPAR-α), a nuclea...

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Bibliographic Details
Main Authors: Pietro Antonuccio, Herbert Ryan Marini, Antonio Micali, Carmelo Romeo, Roberta Granese, Annalisa Retto, Antonia Martino, Salvatore Benvenga, Salvatore Cuzzocrea, Daniela Impellizzeri, Rosanna Di Paola, Roberta Fusco, Raimondo Maximilian Cervellione, Letteria Minutoli
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Nutrients
Subjects:
varicocele
testis
PPAR
TLR4
PEA-um
nutraceutical
Online Access:https://www.mdpi.com/2072-6643/13/3/734

Internet

https://www.mdpi.com/2072-6643/13/3/734

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