Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity

Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity

Male sex determination in mammals is initiated by SRY, a Y-encoded transcription factor. The protein contains a high-mobility-group (HMG) box mediating sequence-specific DNA bending. Mutations causing XY gonadal dysgenesis (Swyer syndrome) cluster in the box and ordinarily arise de novo. Rare inheri...

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Bibliographic Details
Main Authors: Yen-Shan Chen, Joseph D. Racca, Michael A. Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
testis determination
gonadogenesis
organogenesis
protein-DNA recognition
infertility
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.945030/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.945030/full

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