A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation

A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation

Neointima formation is a serious complication caused by mechanical trauma to the vessel. (R)-4,6-dimethoxy-3-(4-methoxy phenyl)-2,3-dihydro-1H-indanone [(R)-TML 104] is a synthesized analog of the natural product resveratrol sesquiterpenes (±)-isopaucifloral F. The present study aimed to investigate...

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Bibliographic Details
Main Authors: Baohui Yuan, He Liu, Xiaoliang Dong, Xiaohua Pan, Xun Sun, Jia Sun, Li-Long Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
(R)-TML104
neointima formation
nicotinamide adenine dinucleotide phosphate oxidase 4
nuclear factor-κB
vascular smooth muscle cells
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.756098/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.756098/full

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