High-affinity decoy protein, nFD164, with an inactive Fc region as a potential therapeutic drug targeting CD47

High-affinity decoy protein, nFD164, with an inactive Fc region as a potential therapeutic drug targeting CD47

CD47, as an innate immune checkpoint molecule, is an important target of cancer immunotherapy. We previously reported that a high-affinity SIRPα variant FD164 fused with IgG1 subtype Fc showed a better antitumor effect than wild-type SIRPα in an immunodeficient tumor-bearing model. However, CD47 is...

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Bibliographic Details
Main Authors: Zhihong Wang, Naijing Hu, Haitao Wang, Yuanyu Wu, Guiqi Quan, Yahui Wu, Xinying Li, Jiannan Feng, Longlong Luo
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CD47
Cancer immunotherapy
SIRPα
NFD164
Inactive Fc
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223004067

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223004067

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