High-affinity decoy protein, nFD164, with an inactive Fc region as a potential therapeutic drug targeting CD47
CD47, as an innate immune checkpoint molecule, is an important target of cancer immunotherapy. We previously reported that a high-affinity SIRPα variant FD164 fused with IgG1 subtype Fc showed a better antitumor effect than wild-type SIRPα in an immunodeficient tumor-bearing model. However, CD47 is...
Main Authors: | Zhihong Wang, Naijing Hu, Haitao Wang, Yuanyu Wu, Guiqi Quan, Yahui Wu, Xinying Li, Jiannan Feng, Longlong Luo |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-06-01
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Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223004067 |
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