The Efficacy and Safety of Polyethylene Glycol Cholesterol- and Tocopherol Polyethylene Glycol 1000 Succinate-Modified Transforming Growth Factor β1 Small Interfering RNA Lipid Nanoparticles in the Treatment of Paclitaxel-Resistant Non-Small-Cell Lung Cancer

The Efficacy and Safety of Polyethylene Glycol Cholesterol- and Tocopherol Polyethylene Glycol 1000 Succinate-Modified Transforming Growth Factor β1 Small Interfering RNA Lipid Nanoparticles in the Treatment of Paclitaxel-Resistant Non-Small-Cell Lung Cancer

The aim of this study was to explore the efficacy and safety of TGFβ1 siRNA lipid nanoparticles (LNPs) modified with different PEG derivatives (PEG5000 cholesterol, abbreviated as CE; tocopherol polyethylene glycol 1000 succinate, abbreviated as TPGS) in the treatment of paclitaxel-resistant non-sma...

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Bibliographic Details
Main Authors: Zhaowu Zeng, Xianglong Zeng, Xinyi Li, Yuxin Feng, Yue Kan, Xingyan Liu, Yiying Zeng
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
PEG cholesterol
tocopherol polyethylene glycol succinate (TPGS)
TGFβ1
siRNA
lipid nanoparticles
paclitaxel-resistant non-small-cell lung cancer
Online Access:https://www.mdpi.com/1999-4923/16/1/75

Internet

https://www.mdpi.com/1999-4923/16/1/75

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